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Effects of exercise training on metabolic and cardiovascular dysfunctions in offspring of fructose animals: role of cholinergic anti‐inflammatory reflex.
Author(s) -
Dias Danielle Silva,
Dos Santos Camila Silva,
Araujo Amanda,
Ferreira Maycon,
Shecaira Tânia,
Carmo Gabriel,
Bernardes Nathalia,
Irigoyen Maria Cláudia,
De Angelis Kátia
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.05404
Subject(s) - offspring , medicine , fructose , blood pressure , weaning , endocrinology , heart rate , biology , pregnancy , biochemistry , genetics
Aim To evaluate the effects of aerobic ET on metabolic and cardiovascular parameters in offspring of fructose‐consuming animals, testing the role of cholinergic anti‐inflammatory reflex in this condition by splenectomy. Methods Offspring of Wistar genitor rats treated with fructose or placebo (water) were divided into 4 groups: sedentary‐water (W), sedentary‐fructose (F), trained‐fructose (TF) and trained‐splenectomized‐fructose (TSF). Fructose overload (10%) was started 30 days after weaning only for the parents and continued until the end of lactation. The offspring received standard feeding and 30 days after weaning the spleen was removed (splenectomy) and the ET was started on treadmill (1h/d, 5d/week, 4 weeks, moderate intensity). After 30 days, the glycemia, blood triglycerides (TG) and insulin tolerance were evaluated. Blood pressure (BP) and heart rate (HR) signals were directly recorded in awake animals through an acquisition system. Results Although no differences in glycemia and insulin tolerance were observed, the TSF group showed an increase in TG compared to W, F and TF groups (166 ± 12 vs. 100±6; 113±11; 110±4 mg/dL). Regarding cardiovascular changes, the F group had increased systolic blood pressure (SBP) compared to W group (F: 127±4 vs. W: 117±2 mmHg). ET prevented the increase in SBP (TF: 118 ± 2 mmHg); however, this benefit was not observed in the TSF group (129±5 mmHg). In addition, diastolic BP was higher in the TSF group (100±6 mmHg) compared to W and TF groups (91 ± 3 and 87 ± 2 mmHg). There was no difference in HR between the groups studied. BP variability was increased in F group in relation to TSF group. Conclusion The consumption of fructose by parents induced early BP changes in offspring, which were prevented by exercise training. In addition, splenectomy abolished the cardiovascular benefits of ET in offspring of fructose rats, suggesting participation of the anti‐inflammatory cholinergic reflex in these adaptations. Support or Funding Information FAPESP: 2018/17183‐4, CNPq (157746/2018‐6) and UNINOVE