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White Matter Hyperintensities and Carotid Arterial Stiffness in Amnestic Mild Cognitive Impairment
Author(s) -
Curtis Bryon Matthew,
Tomoto Tsubasa,
Chiles Collin,
Austin Courtney,
Zhang Rong
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.04592
Subject(s) - arterial stiffness , cardiology , medicine , pulse pressure , hyperintensity , blood pressure , pulsatile flow , pulse wave velocity , magnetic resonance imaging , radiology
White matter hyperintensities (WMH) is a risk factor of cognitive impairment and Alzheimer’s disease (AD). Arterial stiffening is associated with increased arterial pressure and cerebral blood flow (CBF) pulsatility which may lead to WMH pathogenesis. However, the relations among WMH, arterial stiffness, and pulsatile change in arterial pressure and CBF remain unclear. Therefore, this study investigated the associations among WMH volume, carotid arterial stiffness, carotid arterial pressure, and CBF pulsatility in patients with amnestic mild cognitive impairment (MCI), a prodromal stage of AD. Methods Fifty‐four amnestic MCI patients and twenty‐four cognitively normal subjects (CN) underwent measurements of WMH volume using T2‐weighted‐fluid‐attenuated inversion recovery imaging. Carotid β‐stiffness index and arterial pressure at the common carotid artery (CCA) were measured using ultrasound and applanation tonometry. CBF pulsatility index (PI) was measured from the middle cerebral artery using transcranial Doppler. Results WMH volume, PI, carotid β‐stiffness index, carotid systolic blood pressure (cSBP) and pulse pressure (cPP) did not differ between groups. Greater WMH volume was correlated with higher CBF PI in both groups (MCI: r=0.373, NC: r=0.463, p<0.05), whereas it was correlated positively with carotid β‐stiffness index, cSBP, and cPP only in the MCI group (MCI: r=0.499, r=0.432, r=0.468, all p<0.01). In multiple linear regression analysis, cSBP was an independent determinant of WMH (β=0.293, p=0.005) with adjustment for age, sex, body mass index, and MCI status. Conclusion These findings collectively suggest that carotid arterial stiffness, carotid SBP, and pulse pressure may play an important role in WMH pathogenesis in MCI. Support or Funding Information This work was funded by the National Institutes of Health ((R01AG033106, R01HL102457, P30AG012300)