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Molecular and cellular insights into mechanosensation and volume regulation in the nervous system
Author(s) -
Brohawn Stephen
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.04537
Subject(s) - mechanosensation , neuroscience , mechanosensitive channels , nervous system , piezo1 , innovator , ion channel , potassium channel , electrophysiology , cognitive science , biology , psychology , computer science , biophysics , biochemistry , receptor , intellectual property , operating system
The transduction of physical forces into cellular electrical signals is fundamental to a wide breadth of biology including the classic senses of touch, pain, hearing, and balance; less conspicuous sensations of proprioception, blood pressure, and osmolarity; and basic aspects of neural growth, signaling, and death. In this talk, I will discuss recent work aimed at understanding the basis of mechanosensation and volume regulation in the nervous system. First, I will present a model for the mechanism of membrane tension sensing and physiological roles of a mechanosensitive potassium channel based on a combination of structural, electrophysiological, and localization data. Second, I will present a model for ionic strength sensing and channel gating in a family of volume regulated anion channels based on structural and functional studies. Support or Funding Information New York Stem Cell Foundation ‐ Robertson Neuroscience Investigator Award, McKnight Scholar Award, Klingenstein‐Simons Fellowship Award, NIGMS New Innovator Award, Rose Hill Innovator Award