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Genetic Influences on Fall Risk in Patients with Type 2 Diabetes Mellitus
Author(s) -
Quinlan Cody Mcquaid,
Haji Barrawan Awni,
Singleton John David,
Raynes Edilberto Alcantara
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.04530
Subject(s) - medicine , type 2 diabetes mellitus , sarcopenia , diabetes mellitus , psychological intervention , physical therapy , obesity , diabetic neuropathy , endocrinology , psychiatry
Globally, the prevalence rate of obesity is continuously increasing giving rise to a corresponding increasing prevalence of type 2 diabetes mellitus (T2DM). Reflective of this global increase in the field of physical therapy is increased treatment of patients with T2DM who are at increased risk for falls. The purpose of this study was to explore whether physical therapists should implement fall risk prevention interventions based on genetic variants among patients with T2DM. Utilizing PubMed, Google Scholar, and Research Gate studies were identified then ranked using the Oxford Levels of Evidence. Results identified fall risk factors within the scope of a physical therapist and associated with T2DM include diabetic peripheral neuropathy, osteoarthritis and sarcopenia. Genetic variants in NOS1AP, IL‐1 gene cluster and MSTN were identified to be associated with increased development and progression of the above‐mentioned fall risk factors. It can be argued patients with T2DM who present with variants in these genes are more likely to develop increased fall risk. Therefore, these patients should be treated preemptively by the physical therapist. These physical therapy treatments should include interdisciplinary and preventative care for diabetic peripheral neuropathy, osteoarthritis and sarcopenia leading to a decreased development of fall risk. Future studies should focus on preventative physical therapy treatment of genetically identified fall risk factors in patients with comorbidities associated with fall risk.