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Resistance Training with or without Blood Flow Restriction Improves Short‐Term Memory in Rats
Author(s) -
Rebelo Macario Arosti,
Garcia Nádia Fagundes,
Puggina Enrico Fuini,
de Moraes Camila
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.03919
Subject(s) - blood flow restriction , medicine , blood flow , resistance training , psychology , physical therapy , cardiology
Low load resistance training with blood flow restriction is usually used for improvements in muscle strength in special care conditions. However, there is limited information regarding the effects of this exercise approach on memory function. The aim of this study was to investigate the effect of resistance training with or without blood flow restriction, carried out three times a week, on short‐term memory. Male Wistar Hannover rats (70 days old) were divided into four groups: Sedentary Sham (S/S, n=10), Trained Sham (T/S, n=10), Sedentary with blood flow restriction (S/BFR, n=11), Trained with blood flow restriction (T/BFR, n=9). Animals from the S/BFR and T/BFR had their right femoral artery flow restricted (blood arrival and venous return) about 36–38% and animals from sham groups were submitted to the same surgical procedures except blood restriction. Experimental protocol was approved by local ethic committee (protocol: 2016.5.80.90.4). Exercise training began two weeks after surgery procedures. The exercise sessions were carried out three times a week and consisted of climb a vertical ladder (110 cm high, 18 cm wide, 2 cm grid, 80° inclination), carrying a load (50% of 1 Maximum Repetition) for 6 sets of 10 repetitions with 1‐minute rest between sets. After four weeks of exercise training, memory performance was assessed using the Object Recognition Test and the discrimination index ( d I) was calculated ( d I= [(time spent exploring the novel object minus time spent exploring the familiar object)/ total exploration time]). The interval between testing sessions 1 and 2 was 30 minutes. Femoral blood flow restriction did not cause impairment on memory performance (S/S d I =0.33±0.08 vs S/BFR d I =0.37±0.03). On the other hand, exercise training improved memory performance in both groups (T/S d I =0.76±0.07 vs T/BFR d I =0.59±0.04). The resistance training, carried out 3 times a week, was effective to improve short‐term memory either with or without peripheral blood flow restriction. Support or Funding Information Supported by FAPESP Grant # 2017/13348‐6; Grant # 2018/16712‐3