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Ovoceutin TM Attenuates Diarrhea Caused by Porcine Epidemic Diarrhea Virus in Piglets
Author(s) -
Talukder Jamil,
Srivastava Ajay,
Rajamanickam Darwin,
Lall Rajiv
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.03058
Subject(s) - porcine epidemic diarrhea virus , diarrhea , medicine , feces , enteritis , virus , outbreak , virology , ovotransferrin , coronavirus , microbiology and biotechnology , biology , transferrin , disease , infectious disease (medical specialty) , covid-19
Background Porcine epidemic diarrhea virus (PEDV), a coronavirus, infects the small intestinal epithelium of a pig. Older hogs mostly get sick and lose body weight after being infected, whereas newborn piglets usually die within five days of contracting the virus due to enteritis, severe diarrhea, and dehydration. PEDV is highly infectious, resulting in significant morbidity and mortality in piglets ‐ approaching 100% in suckling piglets, which leads to substantial economic burden on pig farms. Controlling enteritis, diarrhea, and dehydration in piglets remains a great challenge to reduce mortality. Lactoferrin and ovotransferrin are iron‐binding multifunctional glycoproteins belonging to the transferrin family, which not only prevent diarrhea but also function as antibacterial, anti‐inflammatory, anti‐viral, etc. In addition, ovotransferrin (Ovoceutin TM ) has been shown to bind with Marek’s disease virus to block binding with host cell in poultry. Thus, Ovoceutin may play important roles in enteritis and diarrhea in PEDV‐piglets. Aim Determine the effects of Ovoceutin on diarrhea caused by PEDV in piglets. Methods Pigs on a farm were diagnosed with PEDV in Wisconsin, USA. Newborn piglets showing severe diarrhea were divided into five groups with five piglets in each group. Ovoceutin was made at an in‐house facility of Vets Plus, Inc. The control group received only electrolytes in 50ml of lukewarm water (EW); treated groups received 1 or 2.5g of Ovoceutin and water, or along with EW, twice a day for five consecutive days. Consistency of feces was scored as watery to solid (1–5), and physical conditions were scored as laying down (1), no response to caretaker (2), or walking (3). Results The control group (EW) showed poor survival rate (40%) while 2.5g of Ovoceutin‐water treated group had a higher survival rate (80%), better fecal score, and physical conditions. EW‐2.5g of Ovoceutin group showed the highest survival rate (100%), best fecal, and physical condition scores. Conclusions We conclude from these results that Ovoceutin TM attenuates diarrhea in PEDV‐piglets and can be used to improve piglets’ digestive health. Support or Funding Information Research and Development Fund, Vets Plus, Inc.Effect of Ovoceutin TM in diarrhea caused by Porcine Epidemic Virus Diarrhea in newborn piglets.