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Environmental noise is a cardiovascular risk factor – mechanistic insights on oxidative stress, inflammatory pathways and endothelial dysfunction and preliminary data from diabetic mice.
Author(s) -
Jimenez Maria Teresa Bayo,
Frenis Katie,
Kalinovic Sanela,
Kvandová Miroslava,
Helmstädter Johanna,
Mirski Ksenija Vujacic,
Oelze Matthias,
Steven Sebastian,
Daiber Andreas,
Münzel Thomas,
Kröller-Schön Swenja
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.02420
Subject(s) - oxidative stress , endothelial dysfunction , diabetes mellitus , medicine , inflammation , hyperlipidemia , risk factor , endothelium , vascular disease , bioinformatics , endocrinology , cardiology , biology
Most traditional cardiovascular risk factors (diabetes, smoking or hyperlipidemia) are associated with vascular complications such as endothelial dysfunction, oxidative stress and inflammation. During the last two decades, large epidemiological studies have shown that the physical environment such as noise from road, aircraft or railway may facilitate the development of cardiovascular and metabolic diseases. These studies have demonstrated a link between the incidence of ischemic heart diseases or metabolic disease such as diabetes and exposure to noise, supporting its role as an independent cardiovascular risk factor (reviewed in the WHO Noise Guidelines for the European Region). We investigated the influence of aircraft noise exposure on molecular mechanisms identifying oxidative stress and inflammation as central players in mediating vascular dysfunction (Münzel et al. Eur. Heart J. 2017; Kröller‐Schön et al. Eur Heart J. 2018). Peak sound levels of 85 and mean sound level of 72 dB(A) applied for 1, 2 and 4 days caused an increase in systolic blood pressure, stress hormones and induced endothelial dysfunction, oxidative stress and inflammation. Control exposures to white noise for 4 days did not induce these changes. The potential additive effects of noise exposure and preexisting diabetes as well as the underlying molecular mechanisms are currently being investigated in a mouse model since the characteristics of noise induced vascular dysfunction considerably resemble the mechanisms of vascular dysfunction observed in diabetes. Support or Funding Information Our experimental studies on noise effects in mice were supported by vascular biology research grants from the Foundation Heart of Mainz and the Boehringer Ingelheim Foundation for the collaborative research group „Novel and neglected cardiovascular risk factors: molecular mechanisms and therapeutic implications”.