Premium
Analysis of FAM19A2/TAFA‐2 function
Author(s) -
Okada Shuichi,
Okada Junichi,
Yamada Masanobu
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.02412
Subject(s) - meal , food intake , zoology , period (music) , medicine , endocrinology , food science , biology , physics , acoustics
FAM19A2/TAFA‐2, a member of the chemokine CC family, shares 31% sequence identity with MIP‐1α, which is known to elevate body temperature and reduce food intake. A single administration of 250 pM of FAM19A2/TAFA‐2 to the third ventricle of mice just before the initiation of dark period increased food intake and meal number significantly, but reduced meal size during the dark period. The respiratory exchange rate and energy expenditure were increased significantly during the dark period, while the ambulatory count and vertical activity were not affected. These data suggest that FAM19A2/TAFA‐2 participates in the regulation of food intake and metabolic activities.Effect of FAM19A2 on Food intake, Meal number, and Meal sizeEffect of FAM19A2 onRER and EE