EFFICACY OF A NOVEL IRON‐FREE VMP35 MULTI‐NUTRIENT COMPLEX IN RESTORING HEMOGLOBIN AND IRON TO RED BLOOD CELLS IN ANEMIC BLOOD: A CLINICAL INVESTIGATION

According to the NHLBI, more than 3 million Americans suffer from Anemia, the most prevalent blood disorder, while anemia affects 1.93 billion people worldwide (24.8% of the world population). Several degenerative diseases are associated with anemia. Substantial loss of blood causes massive alterations in blood parameters including reduced iron leading to anemia. However, it is the authors’ assertion that chronic iron deficiency anemia has been misconceptualized. We hereby propose a new concept termed Chronic Anemia Syndrome (CAS). CAS is the result of a diminishing reservoir of primary alkaline buffers promoting an increased anaerobic/acidic/hypoxic biological environment and pathological events, which are characteristic of almost all chronic degenerative diseases. Diminishing primary alkaline buffers induce chronic inflammatory and pathophysiological conditions promoting a defensive expenditure of secondary alkalinizing buffers from hemoglobin (i.e. histidine), to prevent a dangerous lowering of blood pH. In the process of liberating histidine from heme protein, iron is cleaved from heme groups; rapidly transported out of the blood circulation; and deposited into other vital organs including hepatic tissues, GI tract tissues; bone marrow, etc., Upon examining results of a blood test, the common diagnosis is iron‐deficient anemia. Moreover, excessive accumulation of iron in the tissues can lead to hemochromatosis, also termed “iron‐overload anemia”, a potentially life‐threatening condition. As such, it is the researchers notion that iron deficiency anemia is not actually caused by an iron deficiency; but by a deficiency in alkaline buffers. To test this hypothesis a randomized controlled one‐way cross‐over clinical investigation was conducted in 38 subjects (men = 10; women = 28; age: 22–82 years). This study evaluated the efficacy of VMP35 multi‐nutrient complex (MNC), a non‐iron containing liquid nutraceutical supplement, on the rate of absorption; restoration of hemoglobin; and its effects on various other properties of the blood. Subjects consumed either placebo or VMP35 (30 ml) and held the sample in their mouth for 30 seconds and swallowed, after which blood was taken at 5 min and/or 30 min. We evaluated properties of live blood within 30 seconds of lancing the fingers following meticulous and methodical procedures to critically assess, via a live blood cell imaging (LBCI) technology using phase contrast microscopy, the changes in peripheral blood smears in all 38 subjects. The iron‐free VMP35 caused positive changes in blood including morphological, hematological (including restoration of hemoglobin) and rheological changes 5 min after intake, which were sustained for at least 30 min. Taken together, the VMP35 non‐iron nutraceutical supplement caused remarkable improvements in blood integrity, including blood morphology and rheology, and rapidly and substantially restored hemoglobin in RBCs. No changes in placebos were observed and no adverse events were reported. Support or Funding Information The Study was Partially Sponsored by VNI Inc, Lederach, PA