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Protective effects of Gladiolus psittascinus bulb Aqueous extract on Nicotine induced Hepatotoxicity in Experimental Rats
Author(s) -
Oyetayo Folake Lucy,
Odeniyi Ifeoluwa Adebayo,
Olaseigbe Olajumoke Esther,
Jegede Funmilayo Olusola
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.00601
Subject(s) - superoxide dismutase , catalase , antioxidant , nicotine , chemistry , bulb , oxidative stress , reactive oxygen species , pharmacology , biochemistry , medicine , botany , biology
Aqueous extract of the bulb of Gladiolus psittascinus was evaluated for protective activities in nicotine induced hepatotoxic rats. Biomarker and antioxidative enzyme activities were analysed using standard analytical procedure. Rats were divided into three groups: Control, Nicotine induced hepatotoxic, nicotine induced but treated Gladiolus psittascinus group. Induction of hepatotoxicity in rats led to significant (P<0.05) reduction of antioxidant enzyme activities. Superoxide dismutase activity (μmol/L) decreased from 18.58± 3.50 in control rats to 9.65± 1.00 in the nicotine induced. This was ameliorated on administration of the bulb extract at 100mg/kg body weight to 17.55± 3.23 in the aqueous Gladiolus psittascinus bulb treated group. Catalase activities (μmol/L) increased significantly from 3.65± 1.43 (Nicotine induced group) to 10.65±1.65 in the bulb extract treated group. Furthermore, plasma aminotransferases activities (U/L) in hepatotoxic rats were significantly reduced to control levels in the bulb extract treated group with Aspartate aminotransferase (AST) showing almost a fourfold reduction (16.51±0.70 (induced rats) to 4.21±0.33(bulb extract treated)) while Alanine aminotransferase (ALT) showed a twofold reduction (5.11±0.70 (induced rats) to 2.50±0.34(bulb extract treated)). Hence, the foregoing shows the potentials of Gladilous psittascinus bulb aqueous extract in enhacing the production of antioxidant enzymes required to scavenge reactive oxygen species. This holds promise for its use as diet therapy in the management and control of hepatotoxicity and oxidative stress related disorders. Support or Funding Information Tertiary Education Trust Fund, Nigeria.