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Antihyperlipidemic, Antiperoxidative and Hypoglycemic Effects of Saponins from Solanum anguivi Lam. Fruits in Alloxan‐induced Diabetic Rats
Author(s) -
Molehin Olorunfemi Raphael,
Elekofehinti Olusola Olalekan,
Oyeyemi Ajibade Oluwagbenga
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.00510
Subject(s) - alloxan , lipid peroxidation , diabetes mellitus , antioxidant , superoxide dismutase , catalase , high density lipoprotein , chemistry , cholesterol , malondialdehyde , pharmacology , medicine , endocrinology , biochemistry
Solanum anguivi Lam. fruit is commonly used in folklore medicine for the management of various diseases including diabetes in Nigeria. The present study evaluates the antihyperlipidemic, antiperoxidative, and hypoglycemic activities of saponins from Solanum anguivi fruits in alloxan‐induced diabetes rats. Diabetic rats were treated with saponin (20 – 100 mg/kg) for 21 days. Results indicated that administration of saponins significantly reduced the elevated levels of glucose, decreased total cholesterol (TC), total triglycerides (TG), low density lipoprotein (LDL) and increased high density lipoprotein (HDL) in the serum towards normalcy when compared to the diabetic control (P< 0.05). In addition, saponins exhibited strong inhibition of lipid peroxidation and increased the levels of antioxidant enzymes (superoxide dismutase and catalase) in the serum, liver and pancreas when compared to the diabetic control (P< 0.05). Our results suggest that saponins from S. anguivi fruit can enhance the hypoglycemic, hypolipidemic and antioxidant properties in alloxan‐induced diabetic rats, and may have the potential to be used in the prevention or in the management of diabetes. Support or Funding Information This research received no specific grant from any funding agency in the public, commercial, or not‐for‐profit sectors