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Link between miRNA‐19b and mTOR signaling pathway in cancer prognosis: from meta‐analysis to mechanism exploration
Author(s) -
MAMAN SOURAKA TAPARA DRAMANI
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.00435
Subject(s) - pten , pi3k/akt/mtor pathway , meta analysis , microrna , kegg , carcinogenesis , hazard ratio , biology , pathway analysis , oncology , mechanism (biology) , protein kinase b , medicine , cancer , cancer research , bioinformatics , signal transduction , gene , gene expression , genetics , transcriptome , confidence interval , philosophy , epistemology
AIMS Previous studies came to different conclusions regarding the relationship between miR‐19b and its prognostic value in cancers. Moreover, miR‐19b could affect tumor growth by different pathways mainly targeting PTEN‐PI3K‐AKT which activate mTOR pathway in the downstream. Therefore, we conducted this meta‐analysis to explore the possible correlation between miR‐19b and mTOR in cancers prognosis. Main methods We conducted online search and collected a total of 943 articles. According to different authors cross check and our study including/excluding criteria we at end retained 21 articles with 25 studies in this meta‐analysis. Then TCGA data containing miR‐19b level with cancer progression were obtained using OncomiR. Furthermore, Trial Sequential Analysis (TSA) was performed to determine whether the results of our meta‐analysis could be used in clinical applications. After that, articles regarding the mechanism of miR‐19b in various cancers were analyzed and KEGG pathway database was used to find the main regulatory function of miR‐19b in human cancers. Key Findings Overall hazard ratio results displayed that higher expression of miR‐19b was correlated with shorter overall survival (HRs=1.54, 95%CIs=1.20–1.98) by promoting distant metastasis, but had no relation with disease‐free survival/progression‐free survival (HRs=0.61, 95%CIs=0.31–1.19). TCGA datasets also revealed the tumorigenesis role of miR‐19b. According to TSA results, more evidence are needed to support that miR‐19b had no correlation with DFS/PFS. Exploration of the mechanism revealed the possible link between miR‐19b and mTOR pathway. Significance MiR‐19b might play its pro‐cancer role through mTOR pathway and it is likely to be a therapeutic target for cancers. Support or Funding Information The study was supported by Zhongnan Hospital of Wuhan University Science and Technology, Innovation and Education Fund [Project cxpy2018067] and Zhongnan Hospital of Wuhan University Science and Technology, Innovation and Education Fund [Project ZNPY2017054].