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Hippo‐signaling in Heart Development and Regeneration
Author(s) -
Martin Jim
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.00403
Subject(s) - hippo signaling pathway , regeneration (biology) , microbiology and biotechnology , biology , heart development , transcription factor , heart failure , kinase , gene , medicine , genetics , embryonic stem cell
The mammalian heart regenerates poorly and damage commonly leads to heart failure. The Hippo pathway is an evolutionarily conserved kinase cascade that regulates heart size during development and prevents adult mammalian cardiomyocyte regeneration by inhibiting the transcription cofactor Yap. Recent work indicates that deletion of the Hippo pathway component, Salv , in cardiomyocytes can reverse ischemic heart failure in a mouse model. Further experiments have uncovered Yap target genes and provided insight into the mechanisms by which Yap regulated cardiomyocyte gene expression. I will discuss our latest findings that reveal new insights into heart size control and regeneration.