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RNA, Chromatin, and the Coordinated Control of Gene Expression
Author(s) -
Johnson Tracy
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.00218
Subject(s) - spliceosome , rna splicing , minor spliceosome , chromatin , intron , microbiology and biotechnology , rna polymerase ii , rna , biology , transcription (linguistics) , ribonucleoprotein , genetics , computational biology , gene , gene expression , promoter , linguistics , philosophy
RNA splicing is carried out by a large ribonucleoprotein machine, the spliceosome. Biochemical dissection of the splicing reaction has uncovered dynamic spliceosome rearrangements that are critical for proper recognition of splice sites and removal of introns. Recently, there has been growing evidence that assembly of the spliceosome onto pre‐mRNA occurs co‐transcriptionally, while the RNA polymerase is actively engaged with a chromatin template, which raises the question of how transcription, and more specifically, the state of the chromatin affects spliceosome assembly. Here we describe how conserved chromatin modifications influence spliceosome assembly to affect splicing outcomes and how changes in splicing allow cells to respond appropriately to their environment. Support or Funding Information NIH/NIGMS RO1 GM085474 HHMI 52008140