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Cellular Communication via Adhesion
Author(s) -
Arac Demet
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.00206
Subject(s) - cell adhesion , g protein coupled receptor , adhesion , microbiology and biotechnology , receptor , biology , computational biology , cell , neuroscience , chemistry , signal transduction , genetics , organic chemistry
Adhesion G Protein‐Coupled Receptors (GPCRs) are cell adhesion proteins that mediate cellular communication and play critical roles in embryonic and neural development. Their mechanisms of action remain poorly understood. In the past several years, three‐dimensional structures of adhesion GPCRs and their ligands have been reported at atomic resolutions and revealed distinct protein folds and unique structural features. In this talk, we will discuss these structures which, together with structure‐guided biochemical and functional analyses, provide hints for the mechanisms of trans‐cellular communication at the synapse and other cell‐cell contact sites. Support or Funding Information NIGMS, NIMH, Chicago Biomedical Consortium