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Mechanotransduction through Integrin‐mediated Adhesions
Author(s) -
Schwartz Martin
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.00148
Subject(s) - mechanotransduction , extracellular matrix , integrin , cell mechanics , fibrosis , microbiology and biotechnology , focal adhesion , medicine , stiffness , cell , chemistry , signal transduction , pathology , biology , materials science , cytoskeleton , composite material , biochemistry
Integrin‐mediated adhesions both transmit mechanical tension and sense the mechanical properties of the extracellular matrix such as stiffness and applied strains. Major human pathologies including hypertension, atherosclerosis, heart failure and fibrosis involve altered forces and tissue stiffness, or altered cell sensing of these variables. My lab investigates the basic mechanisms by which cells sense matrix stiffness, applied strains and fluid shear stress, and how these sensing mechanisms contribute to cardiovascular disorders. I will present our latest work on elucidation of these mechanotransduction pathways and their role in cardiovascular remodeling and disease. Support or Funding Information NIH