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Role of the Microbiome on the Modulation of the Intestinal Barrier in LPS Rats
Author(s) -
Peng Zhanglong,
Sundaresan Alamelu,
Bick Diane,
Umar Shahid,
Doursout MarieFrancoise
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.lb65
Subject(s) - firmicutes , neurodegeneration , intestinal permeability , lipopolysaccharide , dysbiosis , biology , microbiome , pathological , neuroscience , immune system , immunology , microbiology and biotechnology , gut flora , pathology , medicine , disease , bioinformatics , bacteria , genetics , 16s ribosomal rna
The Gut‐Brain‐Axis may be associated with gastrointestinal manifestations preceding disorders of cognitive and/or learning process, supporting the hypothesis that the pathological process is spread from the gut to the brain. We showed that exposure to lipopolysaccharide (LPS) to rats exhibits many features associated with early neurodegeneration, including increases in cytokine production, synthesis of neurotrophins, NOS isoforms, α‐synuclein aggregates and immune cell infiltration in the olfactory bulb. We also discovered LPS‐induced endotoxicity to be associated with prevalence of Proteobacteria and low proportion of Firmicutes phyla suggesting dysbiosis. Microbiota may interact with the GBA most importantly via modulation of intestinal barrier. Our preliminary data show intestinal permeability was significantly increased in rats treated with alcohol/LPS by gavage. We postulate leaky guts will increase exposure of intestinal neuronal tissue to bacterial derived pro‐inflammatory products resulting in neuronal pathological alpha‐synuclein aggregates. Support or Funding Information Funding provided for each faculty by his/her institution.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .