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Cardiovascular Reflexes Control Hemodynamic Responses During LPS‐induced Systemic Inflammation in Conscious Rats
Author(s) -
Amorim Mateus R.,
Deus Júnia L.,
Cazuza Rafael A.,
Mota Clarissa M. D.,
Silva Luiz E. V.,
Borges Gabriela S.,
Batalhão Marcelo E.,
Cárnio Evelin C.,
Branco Luiz G. S.
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.lb639
Subject(s) - baroreflex , reflex , medicine , inflammation , sepsis , hemodynamics , systemic inflammation , lipopolysaccharide , anesthesia , heart rate , blood pressure
Lipopolysaccharide (LPS)‐induced systemic inflammation (SI) is associated with hypotension, tachycardia, and multiple organs dysfunctions. SI, a hallmark of sepsis can lead to cardiovascular impairment and death. Considering that the nervous system regulates immunity and that cardiovascular reflexes, i.e. baroreflex, chemoreflex, and Bezold‐Jarish reflex, are important regulators of hemodynamic function, we investigated these cardiovascular reflexes control acutely and 24 hours after LPS‐induced SI. We combined cardiovascular recordings, immunofluorescence and molecular approaches in male Wistar rats that received intravenous administration of LPS (1.5 or 2.5 mg.kg −1 , CEUA #2017.1.585.58.9). LPS induced hypotension and tachycardia and reduction in baroreflex gain. On the other hand, SI caused no significant impairment in hemodynamic responses to chemoreflex and Bezold‐Jarish reflexes, despite an increased number of activated microglia and IL‐1β levels in the nucleus tractus solitarius. The present data are consistent with the notion that cardiovascular reflexes are kept functional even with central nervous system inflammation. These findings provide insights into the mechanisms that regulate the cardiovascular system during SI and indicate that the improvement of these reflexes responsiveness can be useful for the therapeutic management of sepsis. Support or Funding Information FAPESP, CAPES and CNPq This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .