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Co‐delivery of curcumin and fish oil in phospholipid nanoemulsions attenuates motor impairments and neuro‐inflammation in MPTP induced Parkinson's disease rat model
Author(s) -
Dhavamani Sugasini,
Lokesh B.R.
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.lb59
Subject(s) - neuroprotection , mptp , oxidative stress , pharmacology , curcumin , dopamine , parkinson's disease , chemistry , neurotransmitter , medicine , endocrinology , dopaminergic , disease , central nervous system
Parkinson disease (PD) is a major neurodegenerative disorder that affects mostly the elderly persons. More than 10 million people worldwide are living with PD. This disease causes neurofibrillary tangles, loss of neurons, synaptic dysfunction, mitochondrial dysfunction, postular instability, muscular rigidity and neurotransmitter imbalance and also triggers oxidative stress and enhanced inflammatory responses. However, there is no effective treatment for PD at present in spite of growing understanding of the disorder. Recent studies suggest that DHA may be a potential neuroprotective compound for PD. We have earlier demonstrated that nanocurcumin exhibit anti‐inflammatory activity and also reduce oxidative stress. Co‐ingestion of curcumin with omega 3 rich oils also enhanced DHA as well as neurotransmitter levels in rat brain. However their influence on PD has received very little attention. The present study was undertaken to investigate the effects of nanocurcumin along with fish oil containing DHA on behavioral deficits, oxidative damage and related mechanisms in MPTP administered rats. The results demonstrated that rats given nanocurcumin with DHA significantly alleviated motor dysfunction in MPTP administered rats. Biochemical measurements indicated that rats administered with nanocurcumin exhibited increased glutathione levels, reduced ROS, iNOS and malondialdehyde content. Mechanistic studies demonstrated that BDNF and NGF levels were marginally increased in striatum of rats given nanocurcumin with DHA as compared to MPTP administered rats. Rats given nanocurcumin with DHA enhanced the monoamines neurotransmitter levels and protected from dopaminergic neuronal loss. Moreover, DHA along with phospholipid emulsions played a major role as a neuroprotective agent. The DHA level of was significantly improved in all brain regions of rat given nanocurcumin in MPTP administered rats. The phospholipids of PC‐ DHA and PE‐ DHA also significantly enhanced in brain regions of rats given nanocurcumin in MPTP administered rats and restored it to the normal levels in all regions of brain. The novelty of these findings is the demonstration of improved motor functions, striatal neurotransmitters and dopaminergic neuronal loss protection by nano‐curcumin and fish oil enriched in DHA in MPTP intoxicated rats. These results suggest that the co‐delivery of nanocurcumin and DHA containing oil administered in phospholipid emulsions may benefit for the prevention and treatment for PD patients. Support or Funding Information ICMR, CSIR This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .