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Nicotinate supplements slow onset and severity of symptoms in the monosodium iodoacetate (MIA) rat model for osteoarthritis (OA)
Author(s) -
Bellamine Aouatef
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.lb552
Subject(s) - niacinamide , niacin , osteoarthritis , medicine , rheumatoid arthritis , arthritis , gastroenterology , inflammation , nicotinamide , endocrinology , chemistry , biochemistry , pathology , alternative medicine , enzyme
High doses of niacinamide have been used for the treatment of rheumatoid arthritis in humans. However, it is unclear if nicotinate supplementation can slow the onset of osteoarthritis. To assess this possibility, we supplemented Sprague Dawley rats with niacin (80 mg/kg) or niacinamide (400 mg/kg) then induced arthritis using a single intra‐articular injection of mono‐iodoacetate (MIA). Three MIA concentrations (0.5 mg, 1.0 mg and 2.0 mg) were used to simulate mild, moderate and severe OA disease levels. Changes in levels of pain and inflammation were assessed via dynamic weight bearing (DWB) and joint diameter, respectively. Supplementation with niacinamide, but not niacin, led to a significant decrease in knee joint diameter in both the 0.5 mg and the 1.0 mg MIA cohorts, with relatively better effects in the 0.5 mg MIA group presenting with nearly complete reversal of disease at day 14. Nicotinate treatment did not improve the DWB characteristics of these animals. Blinded histopathological examinations showed that niacinamide's favorable clinical outcomes were correlated mostly in the 0.5 mg MIA group. A second, dose‐response study, using the 1.0 mg MIA model, found that supplementation with niacinamide at 130 mg/kg, and niacin at 10 mg/kg, also yielded beneficial outcomes. These results indicate that supplementation with niacinamide may alleviate some OA symptoms in a relative short period of time. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .