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IMPAIRMENT ON CARDIOVASCULAR AND AUTONOMIC ADJUSTMENTS TO ISOMETRIC EXERCISE IN OBESE SUBJECTS: CORRELATIONS WITH INDEXES OF OBESITY
Author(s) -
Silva Reberth Magalhães,
Viana Ariane,
Santos Thiago Lucio,
De Angelis Katia
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.lb474
Subject(s) - medicine , blood pressure , baroreflex , isometric exercise , heart rate variability , waist , cardiology , heart rate , abdominal obesity , endocrinology , autonomic nervous system , obesity , physical therapy
Obese individuals are susceptible to developing hypertension due to impaired sympathetic and/or parasympathetic modulation and reduced heart rate variability (HRV), and baroreflex sensitivity at rest. Isometric exercise is a challenge for the cardiovascular system and may contribute to triggering early changes in susceptible individuals. The aim of the presente study was to investigate cardiovascular parameters and HRV in obese subjects at rest and in response to isometric exercise using a handgrip. We performed metabolic, cardiovascular and autonomic evaluations in healthy and sedentary individuals (21.09 ± 2.35 years) distributed into 2 groups: Obese (OG, n = 06) and Eutrophic (EG, n = 06) at rest and in response to 90 seconds of physical stress with HandGrip (HG, 30% of the maximal load). We observed increased body mass (p = 0.001), abdominal circumference (p = 0.006), waist circumference (p = 0.007), hip circumference (p = 0.002) and BMI (p = 0.001) in OG, characterizing the sample. We did not observe differences between the groups for blood pressure or blood glucose, triglycerides (p = 0.06) and cholesterol. At rest, the OG showed an increase in the cardiac LF band of HRV in absolute values (p = 0.04), which represents na impairment on cardiac sympathetic modulation in comparison to the EG. In addition, the OG showed an exacerbated response for both systolic (SBP, p = 0.02) and diastolic blood pressure (DBP, p = 0.006) immediately post HG when compared to EG. In addition, after 15 minutes of recovery of the HG, SBP (p = 0.01) and DBP (p = 0.002) of EG returned to baseline values, which was not observed in OG. We also observed improved total HRV post HG in EG in relation to resting values (p = 0.001), which was not observe in the OG. We observed positive correlations for both, final DBP and abdominal circumference (r = 0.74, p = 0.02), and for final DBP and fat mass percentages by skin folds (r = 0.73, p = 0.01). Considering that increased waist circumference, % fat mass and BMI are proven cardiovascular risk factors, we observed here that these factors associated with sedentary lifestyle are correlated with exacerbated blood pressure responses to isometric physical stress. Therefore, although young obese individuals are apparently healthy, they may present increase on sympathetic modulation to the heart at rest and impaired responses to isometric exercise, demonstrating early markers of cardiovascular risk in this population. Support or Funding Information Finacial Support: UNINOVE, CAPES, CNPq. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .