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Peripheral Arterial Adaptations to All‐Extremity Aerobic Exercise Training in Type 2 Diabetes
Author(s) -
Sakarya Yasemin,
Hwang ChuehLung,
Lim Jisok,
Kim HanKyul,
Yoo JeungKi,
Handberg Eileen M.,
Hwang MoonHyon,
Petersen John W.,
Holmer Brady J.,
Lapierre Stephanie S.,
Christou Demetra D.
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.lb446
Subject(s) - medicine , aerobic exercise , cardiology , type 2 diabetes , interval training , peripheral , blood pressure , high intensity interval training , heart rate , arterial disease , physical therapy , diabetes mellitus , endocrinology , vascular disease
Type 2 diabetes (T2D) is associated with arterial remodeling and dysfunction which increase the risk for cardiovascular disease (CVD). There is some evidence that aerobic exercise induces arterial adaptations in the exercising limbs, but not in the non‐exercising limbs, suggesting that all‐extremity exercise might be advantageous. However, the optimal exercise training regimen to induce peripheral arterial adaptations in individuals with T2D is unknown. Therefore, the purpose of this study was to compare, in T2D patients, the effects of all‐extremity high‐intensity interval training (HIIT) vs. moderate‐intensity continuous training (MICT) on arterial structure and function in the exercising arms and legs. Thirty‐three sedentary T2D patients (46 to 78 yrs of age; 64 ± 1 yrs; means ± SE), free of CVD, were randomized to HIIT (n = 12), MICT (n = 10), or non‐exercise control group (CONT; n = 11). HIIT and isocaloric MICT were performed on a non‐weight‐bearing all‐extremity ergometer (Airdyne, Schwinn), 4 days/week for 8 weeks under supervision. HIIT consisted of 4×4‐min bouts at 90% of peak heart rate (HRpeak) interspersed by 3‐min bouts at 70% of HRpeak, while MICT consisted of 32 min at 70% of HRpeak. Both HIIT and MICT were preceded by a 10‐min warm‐up and followed by a 5‐min cool‐down at 70% of HRpeak. Arterial diameter (ultrasonography), intima‐medial thickness (IMT; ultrasonography), blood flow (Doppler) and arterial compliance (change in diameter and change in pressure) were assessed at the brachial (arm) and common femoral (leg) arteries at pre‐ and post‐intervention. Following the 8‐week exercise intervention, brachial and femoral diameter, IMT, blood flow and compliance did not significantly change in response to HIIT or MICT (P≥0.1 for group × time interaction). In conclusion, 8 weeks of all‐extremity HIIT and MICT do not lead to arterial remodeling or changes in arterial function in the exercising arms and legs in patients with T2D. Support or Funding Information This work was supported by National Institute of Aging grant AG050203 to DDC. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .