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Chromatin Regulation of Tumor Responses to Immune Checkpoint Blockade
Author(s) -
Shi Yang
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.92.3
Subject(s) - chromatin , immune system , immunogenicity , blockade , immune checkpoint , biology , chromatin remodeling , t cell , immunotherapy , cancer research , immunology , computational biology , genetics , receptor , dna
Recent studies have shown that chromatin regulators impact tumor cell immunogenicity and immune cell functions, thus impacting responses of tumors to the immune system. We have been using genetic tools to identify chromatin regulators that control tumor responses to the immune system, with the ultimate goal of identifying small molecules which would work together with checkpoint inhibitors to curtail cancers. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .