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Prevalence of Thiamine (B 1 ) deficiency in a cohort diagnosed with Postural Orthostatic Tachycardia (POTS)
Author(s) -
Del Pozzi Andrew Thomas,
Blitshteyn Svetlana
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.871.3
Subject(s) - thiamine , medicine , vitamin , vitamin d deficiency , malnutrition , cohort , vitamin d and neurology , medical record , homocysteine , gastroenterology , b vitamins , pediatrics , endocrinology , physiology
Thiamine (vitamin B 1 ), a water‐soluble vitamin that plays a pivotal role in energy metabolism, growth, development and the function of cells. Has been found to be deficient in conditions such as malnutrition, eating disorders, and bariatric surgery complications as well as alcoholism. Previously vitamin B 12 , vitamin D and Iron deficiencies have been noted in patients with POTS. Yet the prevalence of thiamine deficiency and response to thiamine supplementation in POTS has yet to be determined. PURPOSE to determine the prevalence of Thiamine deficiency in those patients diagnosed with POTS. As well as to indicate if supplementation of thiamine affects outcomes. METHODS Sixty‐five consecutive patients (59 women and 6 men) ranging in age from 13 to 54 years old, who met the diagnostic criteria for POTS were evaluated and followed by our clinic. As part of clinic initial diagnostic workup all clinic patients have vitamin panels drawn (Quest Diagnostics Laboratory), thus we reviewed patient medical records noting whole blood vitamin B 1 . Those patients that were found to be deficient in B 1 were given thiamine hydrochloride at 100 mg daily for 4 weeks and then followed up with office exams and self‐report of changes in symptoms. RESULTS Six percent (n = 4) of the patients tested positive for thiamine deficiency. Those that showed deficiency were only mildly deficient (72–77 nm/L vs. Normal 78–185 nm/L). Other vitamin and mineral levels including B 6 , B 9, B 12 , vitamin E, iron, copper, and magnesium as well as homocysteine level were normal in all deficient B 1 patients. All patients were supplemented vitamin B 1 , however, only 25% (n = 1) responded favorably to the supplementation. Although 100% of those supplemented had vitamin B 1 levels returned to the normal range. CONCLUSION A small subset of POTS patients may have vitamin B 1 deficiency. Testing for and correcting the deficiency could prove helpful to those patients. Further research should be done on a larger scale and should include a healthy control group as well as objective measures of improvement such as tilt‐table‐testing as part of the follow‐up. Support or Funding Information none This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .