Premium
The Impact of Caffeine on Dynamic Cerebral Autoregulation in Habitual Consumers
Author(s) -
Pizzey Faith K,
Tourula Erica N,
Theorin Tyler J,
Subudhi Andrew W,
Pearson James
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.855.3
Subject(s) - caffeine , cerebral autoregulation , medicine , adenosine receptor antagonist , middle cerebral artery , autoregulation , anesthesia , adenosine receptor , cerebral blood flow , blood pressure , population , ischemia , receptor , environmental health , agonist
Caffeine is an adenosine receptor antagonist that is consumed daily by 90% of the United States population and can lead to adenosine receptor upregulation. In caffeine‐naïve individuals, drinking caffeine increases dynamic cerebral autoregulation as assessed by the rate of regulation (RoR) but the influence of caffeine in habitual users is unclear. We aimed to investigate whether dynamic cerebral autoregulation in middle and posterior cerebral arteries was altered by caffeine consumption in habituated consumers. Nine healthy subjects (age: 27 ± 6 yrs, Ht: 179 ± 14 cm, Wt: 76.1 ± 13.6 kg) completed three trials where they drank (6.25ml/kg body mass) either caffeinated coffee (CAF; 4mg caffeine/kg body mass), decaffeinated coffee (DECAF), or water (WATER). Before subjects drank anything (pre drink) we measured mean arterial pressure (MAP; mmHg), middle (MCAv; cm/s) and posterior (PCAv; cm/s) cerebral artery blood velocities at baseline and then during two successive thigh occlusion/release protocols to examine dynamic cerebral autoregulation (Rate of Regulation: RoR, 1/s). Subjects were then given one of the three drinks in a double‐blind, counterbalanced design. Thirty minutes later baseline measurements and the assessment of RoR were repeated (post drink). MAP decreased 14 ± 4 mmHg across all trials following thigh cuff deflation in the assessment of RoR pre drink. Pre drink RoR in the MCA was CAF: 0.19 ± 0.13, DECAF: 0.21 ± 0.14 and WATER: 0.21 ± 0.09 1/s. Pre drink RoR in the PCA was CAF: 0.24 ± 0.18, DECAF: 0.16 ± 0.15 and WATER: 0.23 ± 0.12 1/s. MAP increased from pre to post drink (CAF: 84 ± 7 to 98 ± 6 mmHg; DECAF: 88 ± 10 to 95 ± 6 mmHg and WATER: 89 ± 9 to 97 ± 5 mmHg; p = 0.002), but was not different between trials (p > 0.05). MAP decreased 14 ± 3 mmHg across all trials following thigh cuff deflation in the assessment of RoR post drink. Post drink, MCA RoR demonstrated an interaction effect between trial and time (p = 0.047) and a main effect of time (p = 0.042). Post drink MCA RoR increased in the CAF trial relative to pre drink (0.40 ± 0.17 1/s; p = 0.008) but was unchanged in DECAF (0.23 ± 0.12 1/s) and WATER trials (0.23 ± 0.11 1/s) (both p > 0.05 vs. pre drink). Post drink, PCA RoR was not different relative to pre drink (CAF: 0.35 ± 0.13, DECAF: 0.20 ± 0.11 and WATER: 0.21 ± 0.10 1/s) and did not demonstrate a main effect of time (p = 0.335), trial (p = 0.081) nor an interaction effect (p = 0.414). These findings suggest that caffeine consumption increases dynamic cerebral autoregulation in habituated consumers and supports the increased RoR found in the MCA following caffeine administration in caffeine naïve individuals. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .