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Acute Aldosterone Administration Increases Vascular Resistance in Patients with Type 2 Diabetes
Author(s) -
Finsen Stine Høyer,
Mortensen Stefan P
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.834.14
Subject(s) - aldosterone , medicine , type 2 diabetes , endocrinology , blood pressure , mineralocorticoid , hemodynamics , vascular resistance , blood flow , diabetes mellitus , cardiology
Individuals with type 2 diabetes (T2D) have an increased risk of developing macrovascular dysfunctions such as arteriosclerosis and reduced blood flow, which is not improved by blood‐glucose management. Chronic elevations in plasma aldosterone levels could contribute to endothelial dysfunction. A shift in the balance between constrictor and dilator responses to aldosterone could be involved in the detrimental actions of aldosterone. Hypothesis We tested the hypothesis that T2D is associated with a shift from a vasodilator to vasoconstrictor response to aldosterone. Methods In 6 subjects with T2D and 11 control subjects, we measured leg hemodynamics during 5 min of incremental doses of infused aldosterone (0.2 and 5 ng/min/L leg volume) in the femoral artery. Leg blood flow (LBF; ultrasound Doppler) and mean arterial blood pressure (MAP) was measured. Femoral arterial and venous blood samples were also collected. Data was analyzed with a one‐way repeated measures ANOVA (within groups) and two‐way ANOVA (between groups). Results In the subjects with T2D, LBF and leg vascular conductance (LVC) decreased during aldosterone infusion at the high dose ( P <0.05), whereas there was no change in LBF and LVC in the control group. Aldosterone infusion did not change MAP and there was no difference between groups. Venous aldosterone levels increased during infusion of aldosterone in both groups ( P <0.05) and no differences were observed between groups. Conclusion These preliminary results suggest that T2D is associated with a vasoconstrictor response to physiological levels of infused aldosterone. Support or Funding Information Independent Research Fund Denmark and The Region of Southern Denmark This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .