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Vaping During Pregnancy Results in Arterial Stiffness in Offspring
Author(s) -
Aboaziza Eiman,
O'Reilly Juliana,
Moore Josh,
McLaughlin Sarah,
Olfert I. Mark,
Chantler Paul
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.828.18
Subject(s) - medicine , pulse wave velocity , arterial stiffness , offspring , nicotine , pregnancy , cardiology , population , blood pressure , physiology , biology , environmental health , genetics
Electronic cigarettes (Ecigs) are promoted as effective smoking cessation tools, and consequently widely used among pregnant women who are motivated to quit tobacco cigarette smoking. Emerging evidence demonstrates that Ecigs can be dangerous to cardiovascular health. Babies born to women who vape represent a uniquely vulnerable population for this type of exposure, because they may be adversely impacted during a critical developmental period. It is unknown if cardiovascular harm potential of Ecigs without nicotine is conferred to offspring of vaping mothers. Pulse wave velocity (PWV) provides an indirect measure of arterial stiffness (with stiffer vessels having higher PWV) and can be useful for characterizing cardiovascular disease progression. Sprague‐Dawley rat dams were exposed to either nicotine‐free Ecig vapor (Ecig0, Joyetech eGrip OLED using 5‐sec puffs @17.5 W) or ambient air. Exposure consisted of 20 puffs over 1‐hour each day, 5 days/week, and resulted in an average daily TPM of ~120 mg/m 3 . Maternal exposure started on gestational day 2 and continued until pups were weaned (postnatal day 21). Pups were never directly exposed. Left common carotid arteries (LCCA) of 4‐month old pups (n=5 per group) were noninvasively imaged via Doppler ultrasound. PWV was measured using the regional transit‐time (TT) method ( PWV= Δd/Δt ; where d is distance between proximal (downstream to aortic arch) and distal (upstream of bifurcation) points on the LCCA, and t is the arrival time of pulse wave upstroke relative to R‐wave peak on ECG). Repeated (≥3) measurements were made for each variable and averaged. TT measurements were performed using a Vevo2100 ultra high frequency ultrasound platform with heart rate monitoring system (VisualSonics Inc, Toronto, ON, Canada). Results were processed using VisualSonics analysis software. Left common carotid arterial PWV (mean ± SD) in the Ecig0 group (6.6 ± 2 m/s) was significantly higher ( p <0.01) than in the air control group (3.2 ± 0.7 m/s). Offspring exposed to nicotine‐free Ecig vapor in utero had higher PWV than controls, indicating stiffer arteries and an increased risk for cardiovascular disease. Further studies will determine the long‐term implications of this vascular impairment. Clinicians and policy‐makers need to be aware of these risks to discourage pregnant women from using Ecigs (with or without nicotine). Support or Funding Information WVU Cancer Institute Philip R Dino Innovative Research Grant (IMO); APS STRIDE Fellowship (JO); AMIF: NIH S10RR026378, P20RR016440, P30GM103488, P20RR016440, P30GM103488 and U54GM104942 (SM) This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .