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Baicalein Neutralizes Hypercholesterolemia‐Induced Aggravation of Cardiac Oxidative Injury
Author(s) -
AlRejaie Salim Salih
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.818.8
Subject(s) - glutathione peroxidase , tbars , superoxide dismutase , medicine , lipid peroxidation , endocrinology , thiobarbituric acid , lactate dehydrogenase , chemistry , oxidative stress , pharmacology , catalase , antioxidant , cholesterol , creatine kinase , biochemistry , enzyme
Hypercholesterolemia is a global well‐known contributing factor in cardiovascular diseases through provoking cardiac oxidative damage and depleting energy production. Baicalein (BL) is a bioactive polyphenolic flavonoid that has multiple cardiovascular beneficial effects. This study aims to investigate the potential cardio‐protective properties of BL against cardiac oxidative injury in high cholesterol diet (HCD) fed rats. HCD in pellet form was prepared by adding 1% cholesterol + 0.5% cholic acid with normal cholesterol rat chow powder. Eighteen animals were fed with HCD for 10 weeks. At the 6 th week, twelve animals started BL treatment in two doses (25 and 50 mg/kg/day, orally). Histologically, BL protected the myocardial morphology against HCD associated multi‐focal vacuolar degeneration. BL markedly reduced serum total cholesterol (TC), triglycerides (TG), creatine kinase‐B (CK‐B), lactate dehydrogenase (LDH) and creatine kinase‐MB (CK‐MB) levels in hypercholesteremic rats. In cardiac tissue homogenate, the levels of lipid‐peroxidation biomarker, thiobarbituric acid reactive substances (TBARS) were significantly prohibited, while glutathione (GSH) levels were increased markedly by BL in HCD fed rats. In addition, hypercholesterolemia‐induced inhibition of cardiac enzymatic activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) was considerably attenuated by BL treatment. Overall, the current findings elucidated that BL exhibits a promising therapeutic value for cardiac metabolic changes linked with hypercholesterolemia via enhancement of the redox balance. Support or Funding Information Deanship scientific research at King Saud University This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .