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Wound healing property of aerial parts of Coleus vettiveroides
Author(s) -
Ponnan Jeyasekhar M,
Edward Jaslin J,
Johnson Rajasingh K
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.812.1
Subject(s) - coleus , wound healing , traditional medicine , silver sulfadiazine , medicine , pharmacology , surgery , biology , botany
Background Coleus vettiveroides is a Labiatae species native to India. In Kenya, the leaves of some species within this genus having diterpenes, triterpenes and flavones compounds were used traditionally for treating the cough. However, to our knowledge, there is no experimental study in supporting its pharmacological activities. Hypothesis We hypothesize that topical administration of ethanolic extracts from the leaves of C. vettiveroides enhances wound healing in rat model. Methods and Results Four groups of male albino rats were selected (n=6) in this study. Full thickness of excisional circular wounds approximately 10 mm diameter were inflicted on the clear skin cutting under anesthesia. A diagrammatic representation of the murine wound‐healing model is presented in the figure. The ointment developed namely ethanolic extract of C. vettiveroides (EEVS) 2.5 mg/g and 5 mg/g was applied twice a day topically to 2 nd and 3 rd group respectively for 15 days. Whereas, the 1 st group applied with simple ointment serve as negative control and the 4 th group applied with silver sulfadiazine (10 mg/gm) topically serves as positive control. Wound contraction was measured on day 2, 4, 6, 8,12,14 and 15. The measurements were compared to the control groups. On day 15, the wounds treated with the EEVS show a significantly reduced wound size and a better wound healing effect both physiologically and histologically when comparted to the control groups. These results suggest that EEVS ointment has the wound healing potential. Conclusion Overall, these data suggest that the ethanolic extract from leaves of C. vettiveroides has the wound healing activity. Thus, these plant extracts have a therapeutic application.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .