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Identification of recurrent fusion genes across multiple cancer types
Author(s) -
Luo Jianhua,
Michalopoulos George,
Yu Yanping
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.802.32
Subject(s) - fusion gene , cancer , breast cancer , colorectal cancer , cancer research , gene , ovarian cancer , biology , genetics
Chromosome changes are one of the hallmarks of human malignancies. Chromosomal rearrangement is frequent in human cancers. One of the consequences of chromosomal rearrangement is gene fusions in the cancer genome. We have previously identified a panel of fusion genes in aggressive prostate cancers. In this study, we showed that 6 of these fusion genes are present in 7 different types of human malignancies with variable frequencies. Among them, the CCNH‐C5orf30 and TRMT11‐GRIK2 gene fusions were found in breast cancer, colon cancer, non‐small cell lung cancer, esophageal adenocarcinoma, glioblastoma multiforme, ovarian cancer and liver cancer, with frequencies ranging from 12.9% to 85%. In contrast, four other gene fusions (mTOR‐TP53BP1, TMEM135‐CCDC67, KDM4‐AC011523.2 and LRRC59‐FLJ60017) are less frequent. Both TRMT11‐GRIK2 and CCNH‐C5orf30 are also frequently present in lymph node metastatic cancer samples from the breast, colon and ovary. Thus, detecting these fusion transcripts may have significant biological and clinical implications in cancer patient management. Support or Funding Information NCI, DOD and UPCI This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .