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Suppression of NLRP3 inflammasome activation in LPS‐induced RAW264.7 cells by natural compound Lava Spirulina maxima extract
Author(s) -
Chei Sungwoo,
Song JiHyeon,
Seo YoungJin,
Lee Kippeum,
Jin Heegu,
Oh HyunJi,
Oh JaeHoon,
Lee BooYong
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.795.3
Subject(s) - antioxidant , spirulina (dietary supplement) , phycocyanin , chemistry , inflammasome , biochemistry , cyanobacteria , lipopolysaccharide , food science , biology , bacteria , immunology , receptor , raw material , organic chemistry , genetics
Spirulina is microscopic filamentous cyanobacteria. Although the Spirulina was recently reported to exert beneficial effect such as reducing cholesterol or weight loss, the correlation of Spirulina and inflammatory response has not been confirmed. The interesting about effect of functional food or nutritional value of blue‐green algae has been increased. Spirulinal maxima was recently reported to exert beneficial effect which contains high amounts of protein, lipids, essential amino acids, minerals, vitamins, photosynthetic pigments, and biologically active substance such as phycocyanin, chlorophyll, beta‐carotene. We choose RAW264.7 cell line, murine macrophages cell to evaluate the effect of Spirulina maxima. We demonstrated that Lava seawater Spirulina maxima 70% ethanol extract (LSME) effectively inhibited the Lipopolysaccharide (LPS) ‐ induced inflammatory response through antioxidant activity. It is also decrease ROS production by down regulating oxidant. LSM is the source of antioxidant which can protect against oxidative damage. Tumor necrosis factor‐alpha (TNF‐α) and interleukin 1β (IL‐1β) is decreased the LPS‐induced overproduction by LSME. We demonstrated that reducing the NLRP3(Nucleotide‐binding oligomerization domain) inflammasome through inhibit MAPK pathway by LSME. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .