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Ishige okamurae Extract Reduces Obesity in High Fat Diet‐Induced Obese Mice
Author(s) -
Seo YoungJin,
Song JiHyeon,
Chei Sungwoo,
Lee Kippeum,
Jin Heegu,
Oh JaeHoon,
Oh HyunJi,
Lee BooYong
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.795.17
Subject(s) - lipolysis , adipogenesis , obesity , medicine , endocrinology , adipose triglyceride lipase , lipase , triglyceride , adipose tissue , chemistry , enzyme , biochemistry , cholesterol
Obesity is caused by an imbalance of energy intake and physical activity. A number of pharmaceutical agents exist to reduce body weight‐related symptoms of obese patients. Ishige okamurae is brown algae and has anti‐oxidant and anti‐inflammatory activities. However, it has not been reported that Ishige okamurae has anti‐obesity property. In our study, we identified that Ishige okamurae extract (IOE) suppresses high fat diet (HFD)‐induced obesity through modulation of adipogenesis and lipolysis. IOE fed mice decreased body and WAT weight. The expression of adipogenic factors such as CCAAT/enhancer binding protein alpha (C/EBPα) and peroxisome proliferator‐activated receptor gamma (PPARγ) were decreased by IOE. Additionally, IOE up‐regulated expression of lipolysis related enzymes such as adipose triglyceride lipase (ATGL) and hormone‐sensitive lipase (HSL). Therefore, our results suggested IOE suppresses adiposity through reduction of adipogenic and enhance of lipolytic‐related factors. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .