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Flame Retardant, Hexabromocyclododecane, Alters Secretion of Interleukin 6 from Human Immune Cells
Author(s) -
Shelby Elizabeth M.,
Falconer April,
Whalen Margaret M
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.792.13
Subject(s) - hexabromocyclododecane , secretion , immune system , peripheral blood mononuclear cell , monocyte , chemistry , lymphocyte , cytokine , immunology , fire retardant , biology , biochemistry , in vitro , organic chemistry
Hexabromocyclododecane (HBCD) is a brominated flame retardant compound. It is used in polystyrene insulation, accumulates in living organisms and is highly toxic to aquatic organisms. Interleukin 6 (IL‐6) is a pro‐inflammatory protein that is produced by T lymphocytes and monocytes (as well as other cells). It regulates cell growth, tissue repair, and immune functions. Previous studies have shown that HBCD alters the secretion of cytokines IL‐1β, TNFα, and INFγ from human immune cells. Due to the important role IL‐6 plays in immune responsiveness, it is important to understand whether exposures to HBCD are able to disrupt its secretion. HBCD is found in human blood and previous studies have shown that it inhibits the ability of human NK lymphocytes to destroy tumor cells. This study examines whether HBCD affects the secretion of IL‐6 from monocyte‐depleted (MD) human peripheral blood mononuclear cells (PBMCs). IL‐6 secretion was measured by enzyme linked immunosorbent assay (ELISA). Results indicate that exposures of MD‐PBMCs to different concentrations of HBCD (ranging from 5–0.05 μM) for 24 h increase secretion of IL‐6 from these immune cells. Thus, exposure to HBCD may potentially disrupt the immune regulation mediated by IL‐6. Support or Funding Information Supported by NIH grant 2 T34GM007663. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .