Premium
Cell Death Induced by Airborne Particulate Matter in Murine Microglial Cells
Author(s) -
Street Mikayla Elizabeth,
Merrill Luke,
Mazzer Paula
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.786.4
Subject(s) - particulates , neurodegeneration , programmed cell death , apoptosis , cell type , chemistry , cell , medicine , pathology , biochemistry , disease , organic chemistry
Airborne particulate matter has been linked to neurodegeneration in recent epidemiological studies. Previous work in our lab has shown that different types of particulate matter elicit different reactions. We set out to investigate two different particulate matter types in microglial cells to see whether they would have the same effect in different types of neurological cells. We combined caspase‐3 assay with lipid profiling to determine the mode of cell death induced by several different types of airborne particulate matter. Some types of particulate matter induced cell death via apoptosis and others induced cell death by neuroinflammatory methods. Support or Funding Information Research reported in this publication was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P20GM103443. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .