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Long noncoding RNAs in immune response and inflammation
Author(s) -
Mandal Subhrangsu S,
Obaid Monira
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.778.5
Subject(s) - hotair , immune system , inflammation , biology , chemokine , long non coding rna , microbiology and biotechnology , osteoimmunology , immunology , lipopolysaccharide , innate immune system , acquired immune system , cancer research , rna , gene , genetics , activator (genetics) , rankl
The mammalian immune system orchestrates innate and adaptive immune responses that are complex biochemical processes regulated by various protein and lipid mediators such as cytokines, chemokines, hormones, growth factors, and others. The emerging evidences suggest that non‐coding RNAs (ncRNAs) play vital roles in regulation of immune responses. In a recent study, we discovered that lncRNA HOTAIR plays critical roles in immune response and inflammation. HOTAIR expression is induced in immune cells (macrophages) upon treatment with lipopolysaccharide (LPS) or peptidoglycan, which are components of bacterial cell membrane. HOTAIR is required for LPS‐induced expression of cytokines and pro‐inflammatory genes. HOTAIR regulates activation of NF‐κB and its target gene (IL‐6 and iNOS) expression via facilitating the degradation of IκBα. Thus, HOTAIR appear to be a critical player in NF‐κB activation in macrophages suggesting its potential functions in inflammatory and immune response. Beyond HOTAIR, we also performed RNA‐Seq analysis on macrophages and identified novel lncRNA associated with immune response and inflammation. Overall, lncRNA appear to be play critical roles in immune response and inflammation and are misregulated in inflammatory disease. Support or Funding Information National Institute of Health‐ 1R15HL142032 This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .