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Weight losing on gastric restriction in an animal model
Author(s) -
Akamatsu Flávia Emi,
Itezerote Ana Maria,
Saleh Samir,
Hojaij Flávio,
Andrade Mauro,
Martinez Carlos Augusto Real,
Jacomo Alfredo Luiz
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.767.31
Subject(s) - medicine , weight loss , analysis of variance , obesity , stomach , animal model , overweight , bonferroni correction , surgery , gastroenterology , statistics , mathematics
Background Obesity and its related comorbidities have detrimental effects for the affected individual and pose a major challenge on public health systems worldwide. The number of non‐surgical options to treat obesity are limited and the long‐term success of dietary or life style interventions is minimal Bariatric surgery leads to a long‐term reduction in body weight and in obesity‐related morbidity and is currently the only treatment modality with a proven mortality benefit. In this regard, research with animal models has significantly helped to elucidate some of the potential mechanisms underlying bariatric surgery. There is no information about gastric restriction with phytobezoar in animal model and the weight loss. Purpose Measure the weight loss until 10 days after surgical gastrostomy and compare to sham and normal group Methods Experimental model of gastric restriction was devised using rats. The animals were submitted to surgical gastrostomy and a cylindrical loofah is inserted into the stomach. We studied 30 adult male Wistar rats divided in three groups: the stomach reduction group (R10), the sham group (S10), which underwent the same procedure except for the loofah insertion and the control group (C10). Animals were fed and kept in separate cages. They were weighed every other day until being sacrificed on day 10. The results will always be described by the mean value with respective standard deviation. Comparison of multiple groups was performed using analysis of variance (ANOVA) followed by Bonferroni post hoc tests. All tests were applied with 5% significance level. Results The weight decreased significantly 9% in the first three days and then increases 6.2% until the weighing of third day and keep until the tenth . This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .