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Impaired Regulation of Peripheral Blood Flow and Blood Pressure in Adults with Down Syndrome
Author(s) -
Hilgenkamp Thessa,
Wee Sang Ouk,
Hong Kwangseok,
Schroeder Elizabeth,
Baynard Tracy,
Fernhall Bo
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.746.7
Subject(s) - supine position , medicine , blood pressure , blood flow , hemodynamics , heart rate , cardiology , brachial artery , peripheral , forearm , mean blood pressure , anesthesia , surgery
Individuals with Down syndrome (DS) exhibit autonomic dysfunction in response to various sympathoexcitatory stimuli, with blunted responses in heart rate and blood pressure (BP). This abnormal central hemodynamic regulation may also affect peripheral blood flow regulation. Preliminary investigations suggest an impairment of brachial blood flow regulation in response to a sympathetic stimulus (−20 mmHg lower body negative pressure (LBNP)), but a larger sample is needed to confirm these findings. PURPOSE To investigate differences in brachial blood flow and BP in response to LBNP between individuals with DS and a control group. METHODS After 10 min of supine rest, participants with DS (n=19, 13 men, 24.0 ± 4.3 years) and age‐matched controls (n=30, 16 men, 24.2 ± 4.0 years) underwent 5 min of LBNP stimulation (−20 mmHg). Blood pressure and brachial blood flow were obtained for analysis in the last minute of baseline and LBNP. Mean flow velocity and arterial diameters were recorded with ultrasonography to determine brachial blood flow (BBF), forearm vascular conductance (FVC), and shear rate. RESULTS Mean arterial pressure (MAP) decreased significantly in the DS group during the LBNP stimulus, with no change in the control group (interaction, p=0.027). The LBNP also produced differential blood flow responses between groups. Mean velocity (p=0.016), FBF (p=0.021), FVC (p=0.012), and shear rate (p=0.013) were different between groups at baseline and only decreased in response to LBNP in the controls (see table). CONCLUSION Young adults with DS exhibit reduced peripheral blood flow regulation in response to LBNP compared to controls, with an abnormal response in blood pressure to LBNP. Further research is required to explore the impact of this blunted sympathetic control of blood flow and blood pressure on exercise and work capacity. Support or Funding Information This work has been supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NIH K99/R00 1 K99 HD092606‐01). This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .