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Neural activity and network during cognitive tasks in heat‐stressed individuals
Author(s) -
Kobayashi Fumino,
Nakata Hiroki,
Shibasaki Manabu
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.738.6
Subject(s) - cerebral blood flow , electroencephalography , heat stress , cognition , functional magnetic resonance imaging , hypocapnia , neuroscience , elementary cognitive task , psychology , medicine , audiology , anesthesia , physics , acidosis , atmospheric sciences , hypercapnia
Reductions in cerebral blood flow accompanying heat stress‐induced hypocapnia via hyperventilation are likely to decrease the cognitive function, but the mechanism remains unknown. Using electroencephalographic event‐related potentials (EEG‐ERP) and functional magnetic resonance imaging (fMRI), we evaluated temporal (EEG) and spatial (fMRI) characteristics during cognitive tasks in heat‐stressed humans. Healthy young volunteers performed a visual cognitive task (Go/No‐go task) before (i.e., normothermia) and during heat stress on separate days. The external canal temperature during heat stress was increased by ~ 1.1°C from the normothermic condition. Decreased cerebral blood flow during heat stress was confirmed by reductions in middle cerebral artery blood velocity (MCAV) and internal carotid blood flow in the EEG‐ERP trial. The amplitudes of the Go‐P300 (i.e., execution) and No‐go‐P300 (i.e., inhibition) components were decreased during heat stress. In the fMRI trial, we observed broadly activated brain regions, including the dorsolateral and ventrolateral prefrontal cortices, and motor‐related areas such as the supplementary motor area and premotor area during heat stress rather than during normothermia. These results suggest that heat stress increases the load of neural activity while performing cognitive tasks, relative to normothermia, while heat stress reduced cerebral blood flow and neural activity. Support or Funding Information JSPS KAKENHI 18H03166 This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .