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The effects of fermented milks on physiological and neurobehavioral changes in male Sprague Dawley rats
Author(s) -
Choi Jeonghyun,
Kim JooHeon,
Ham JunSang,
Hong Yonggeun
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.724.2
Subject(s) - melatonin , circadian rhythm , medicine , endocrinology , sleep (system call) , anxiety , pineal gland , cecum , psychiatry , computer science , operating system
Melatonin is a neurohormone secreted by pineal gland and shows pluripotent functions such as anti‐inflammation, anti‐oxidation, and neuronal cell survival. The major function of melatonin is to control circadian rhythm, from awakening to sleep. Recently, many useful items emitting bright light at night time including light emitting diode (LED) and smartphone, have been emerged. They give convenience to human life, however, can cause various diseases including sleep deprivation, cancer, and obesity. Sleep disturbance by light exposure at night can lead to anxiety‐like behavior, depression, and decreased cognitive function. Therefore, this study aims to identify the effects of three types of fermented milks (FM); C, T1, T2, on sleep and neurobehaviors. Experimental animals were randomly divided into four groups; Cont (control croup), C (treatment with type C FM), T1 (treatment with type T1 FM), and T2 (treatment with type T2 FM). To determine the intestinal activation, the length from cecum to colon was measured. In T2 group, cecum/colon length was significantly increased compared to the length of other groups. To evaluate the sleep quality, electroencephalogram (EEG) was measured through intracranial electrode implantation surgery. C, T1, and T2 FM treated groups showed increased activation of δ‐wave than Cont group. Also, neurobehavioral changes were positively improved in T2 group compared to other groups. In addition, melatonin concentration containing in C, T1, and T2 was 56.0 pg/g, 77.6 pg/g, and 504.4 pg/g, respectively. Therefore, melatonin in fermented milk might have positive effects on gut‐brain bidirectional communication. Support or Funding Information NRF‐2017R1A2A2A01067169, KGM4611821, 2016 Creative Research Program of Inje University, Republic of Korea This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .