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A Single Resistance Exercise Session Reduces High‐Fat Meal‐Induced Impairments in Conduit Artery Function and Microvascular Reactivity
Author(s) -
Tomko Patrick M,
Colquhoun Ryan J,
Banks Nile F,
Sciarrillo Christina M,
Koemel Nicholas A,
Emerson Sam R,
Jenkins Nathaniel DM
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.699.3
Subject(s) - meal , medicine , cuff , crossover study , heart rate , cardiology , repeated measures design , endothelial dysfunction , analysis of variance , blood pressure , endocrinology , anesthesia , surgery , placebo , statistics , alternative medicine , mathematics , pathology
OBJECTIVE To examine the effects of full‐body resistance exercise on endothelial function and microvascular reactivity following a high‐fat meal (HFM) in healthy men. METHODS Seven males (mean ± SD, age = 22.1 ± 2.2 y, BMI = 26.5 ± 2.0 kg/m 2 ) participated in this randomized, repeated measures, crossover study. Participants visited the laboratory for familiarization and baseline heart rate and blood pressure measurements. They returned to the laboratory and completed either a session of resistance exercise (RE), consisting of 3 sets of 8 exercises using a 12‐repetition maximum load, or no exercise (NE) and consumed a protein shake (300 – 400 kcals; protein = 0.3g protein per kg body mass) as their last meal. In each condition, the participants returned to the laboratory following a 12‐h overnight fast and consumed a HFM (12 kcal/kg, 63% fat, 34% carbohydrate). Endothelial function was assessed via flow‐mediated dilation (FMD %) and microvascular reactivity was assessed via tissue oxygen saturation (StO 2 ) recovery kinetics of skeletal muscle using a near‐infrared spectroscopy device following vascular occlusion prior to, and 1‐, 3‐, and 5‐h post‐meal. Repeated measures ANOVAs were used to examine condition‐ and time‐based differences in FMD %, minimum tissue saturation (StO 2 min), StO 2 desaturation rate during cuff occlusion (Slope 1), StO 2 reperfusion rate (Slope 2), and StO 2 area under the curve (AUC) for 3 minutes post‐cuff release. RESULTS There was a significant condition × time interaction for FMD% (F (3, 18) = 5.41; p = 0.01). FMD% did not change (p = 0.97) in response to the HFM in the RE condition, whereas it decreased from baseline to 3‐ (p = 0.02, % decrease = −53%) and 5‐h (p = 0.03; −64%), respectively, in the NE condition. Consequently, FMD% was 39% and 53% greater in the RE than NE condition 3‐ (p = 0.01) and 5‐h (p < 0.01) post‐HFM, respectively. There were no condition × time interactions (p > 0.05), but there were condition main effects for StO 2 Slope 2 (F (1, 6) = 12.5; p = 0.01) and StO 2 min (F (1, 6) = 7.5; p = 0.03), where StO 2 Slope 2 was steeper and StO 2 min was lower in the RE than NE condition. There was also a condition × time interaction for StO 2 AUC (F (3, 18) = 3.9; p = 0.03). Statistically, StO 2 AUC did not change in response to the HFM in the RE (p = 0.15) or NE (p = 0.30) conditions. However, StO 2 AUC was 19% (p ≤ 0.05), 28% (p < 0.001), and 12% greater (p = 0.01) at 1‐, 3‐, and 5‐h post‐HFM in the RE than NE condition. There was no significant condition × interaction (p = 0.59), or main effects for condition (p = 0.08) or time (p = 0.93) for StO 2 Slope 1. CONCLUSION A single session of full‐body resistance exercise ameliorates HFM‐induced endothelial dysfunction and improves microvascular reactivity in young, healthy men. These improvements may be mediated by an increase in skeletal muscle metabolism. Resistance exercise could be used as an intervention to improve macro‐ and microvascular responses in the post‐prandial state, which may ultimately reduce cardiovascular risk.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .