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Stress Response of Salivary Chromogranin A and Non‐Invasive Sympathetic Activity Monitoring by Wavelet Transform Analysis in Hypertensive Subjects
Author(s) -
Yajima Yoshiharu,
Mitsubayashi Hiromi
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.692.1
Subject(s) - chromogranin a , blood pressure , medicine , heart rate , cardiology , biomarker , blood sampling , immunohistochemistry , biochemistry , chemistry
Background Stress is one of the risk factor in cardiovascular disease. However, stress induced cardiovascular response is very difficult to estimate because those response are varied in each individuals. A stress marker, salivary chromogranin A, is considered to be a useful tool for patients without any painful stress such as sampling blood test. Furthermore, this method is ease to sampling by any kind of paramedical staffs. We try to estimate the stress induced cardiovascular response both mental stress and physical stress by using salivary chromogranin A. Method Total 18 adults (30 to 65 years old), 9 of essential hypertensive patients and 9 of healthy or non‐hypertensive cardiovascular disease patient were recruited in a local clinical hospital as volunteer measured salivary chromogranin A and change in blood pressure and heart rate induced by mental arithmetic stress or handgrip physical stress, using tonometry blood pressure measurement devise and electrocardiogram those data were collected to laptop computer recording and analyze for sympathetic nerve activity index and parasympathetic nerve activity index by wavelet transform analysis software, simultaneously. Results Although personal stress level were different in each individual, 61% of subjects increase salivary chromogranin A and increase blood pressure and heart rate after mental arithmetic stress. Conclusion Salivary chromogranin A could be useful biomarker for detecting stress sensitive individuals without painful blood sampling, which may be helpful to detect stress sensitivity in clinical patients to prevent cardiovascular events. Support or Funding Information none. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .