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The association of family history of hypertension and overweight induced early impairment in markers of oxidative stress and in heart rate variability
Author(s) -
Viana Ariane,
Silva Dias Danielle,
Nascimento Mario Cesar,
Santos Fernando,
ConsolimColombo Fernanda Marciano,
Irigoyen Maria Cláudia,
De Angelis Kátia
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.691.11
Subject(s) - overweight , oxidative stress , medicine , heart rate variability , cardiology , heart rate , blood pressure , endocrinology , obesity , gastroenterology
Considering the high prevalence of hypertension worldwide and the changes in lifestyle, the understanding of the mechanisms involved in the genesis of hypertension are important to reach more precise interventions. Our objective was to evaluate cardiovascular, autonomic and oxidative stress parameters in individuals with family history of hypertension (FH) with or without overweight. We performed a cross‐sectional study and selected 65 healthy sedentary men (24.08 ± 5.84 years) distributed into 4 groups: negative FH eutrophic (FNE, n=18) or with overweight (FNO, n=19) and positive FH eutrophic (FHE, n=17) or with overweight (FHO, n=17). The heart rate variability (HRV) was analyzed at rest by spectral analysis. The oxidative stress markers were evaluated in plasma. A positive correlation between levels LDL and WC/HC ratio was demonstrated (r: 0.54 p = 0.003) in FHE and FHO groups. We observed an increase in diastolic blood pressure in the FHO and FNO groups in relation to the FNE and FHE groups (p = 0.010). When we evaluated the cardiac sympathetic modulation (LF‐PI), we observed a significant increase in the FNO and FHO groups when compared to the FNE group (p = 0.0001). Furthermore, the FHO (2.30 ± 0.8) and FHE groups (2.52 ± 1) presented higher cardiac sympato‐vagal balance (LF/HF) compared to FNO (1.85 ± 0.67) and FNE groups (2.01 ± 0.84) (p =0.04). We observed an increase in systemic hydrogen peroxide concentration in the FHO group when compared to the other groups (p=0.003). Moreover, there was an increase in NADPH oxidase in plasma in FNO and FHO groups in relation the FNE and FHE groups (p = 0.04). In addition, there was an increase in plasma nitrite levels in FHO group compared to FNO, FNE and FHE groups (p=0.01). In conclusion our findings demonstrated that despite young and apparently healthy, the group with overweight and FH showed early impairment in HRV and in markers of oxidative stress. In addition, this group presented all dysfunctions observed in the presence of these risk factors alone, which may be associated with increased cardiovascular risk and target organ damage in this population. Support or Funding Information UNINOVE, CNPq, CAPES, FAPESP. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .