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Differential Renal and Lumbar Sympathetic Nerve Activation Following Myocardial Infarction in Rats
Author(s) -
Yoshimoto Misa,
Ikegame Shizuka,
Hyodo Fumi,
Shiwa Yuki,
Miki Kenju
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.690.7
Subject(s) - medicine , anesthesia , heart rate , myocardial infarction , lumbar , blood pressure , rate pressure product , cardiology , surgery
Sympathetic nerve activation is considered an important contributor to mortality following acute myocardial infarction (MI). However, few studies have directly monitored sympathetic nerve activity (SNA) in response to acute MI. Herein, we directly and continuously monitored renal SNA (RSNA) and lumbar SNA (LSNA) before and after MI induced by left anterior descending artery (LAD) ligation. Wistar rats were instrumented with a telemetry transmitter and bipolar electrodes for continuous measurement of mean arterial pressure (MAP), heart rate (HR), RSNA, and LSNA. At 7 days after initial surgery, MAP, HR, RSNA, and LSNA were monitored continuously for 28 days. After 4 days of baseline measurements, rats received either LAD ligation via left thoracotomy (MI group; n=13) or sham surgery (n=11) under inhalation anesthesia. Rats in the MI group were subdivided into those that survived for 24 days (MI‐survivor group) and those that died within 3 days (MI‐3d group) after LAD ligation. Transthoracic echocardiography was performed before and aftJSOn day 1 in the MI‐3d group, LSNA increased by 202% ± 28% and MAP decreased by 38±4 mmHg compared with baseline values, while there were no changes in RSNA and HR. On day 1 in the MI‐survivor group, LSNA showed a trend towards an increase compared with baseline values, while there were no changes in RSNA and HR. In the MI‐survivor group, RSNA increased gradually from day 9, and peaked at day 24 (27%±14%) compared with the sham group, while there were no significant changes in MAP, HR, or LSNA. These data suggest that the RSNA may play an important role in compensating for impaired cardiac performance caused by MI, and that the LSNA and RSNA respond differently and in a region‐specific manner to MI. Support or Funding Information JSPS Grant. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .