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Dynamic Carotid Pressure‐Area Relation across the Adult Lifespan
Author(s) -
Tarumi Takashi,
Tomoto Tsubasa,
Sugawara Jun
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.688.10
Subject(s) - arterial stiffness , cardiology , medicine , pulse pressure , pulse wave velocity , blood pressure , carotid arteries
Carotid arterial stiffness is an established risk factor for cerebrovascular disease; however, its structural property in response to pressure pulsatility remains unclear. Therefore, we investigated the dynamic association between carotid artery pressure (CAP) and area (CAA) in healthy individuals across the adult lifespan. Methods 108 participants (age range=19–85 years, 43% women) were tested. The CAA and CAP waveform were measured simultaneously from the bilateral common carotid arteries using applanation tonometry and ultrasonography respectively. To account for individual vessel size differences, CAA was normalized to the mean value and expressed in percentage. The CAP and CAA waveform were fast Fourier transformed to calculate power spectral densities (PSD), then transfer function analysis was used to estimate CAP‐CAA gain and coherence function. Results Older adults showed higher systolic and pulse pressure than younger adults. Systemic arterial stiffness, as assessed by brachial‐ankle pulse wave velocity, was also elevated in older adults. Spectral analysis revealed that PSD of CAP increases whereas that of CAD decreases with advancing age, and most of the age‐related differences are observed below ~4 Hz (Figure A). Furthermore, transfer function analysis exhibited the progressive reductions of CAP‐CAD gain in middle‐aged (0.264±0.087%/mmHg) and older adults (0.232±0.092%/mmHg) when compared with younger adults (0.414±0.166%/mmHg), while its coherence function remained at similar levels (Figure B). Conclusions The dynamic CAP‐CAA gain is significantly reduced in middle‐aged and older adults compared to young adults. These findings suggest that the structural property of the carotid artery is altered during middle age which may increase the risk of cerebrovascular disease incidence. Support or Funding Information This work was supported by JSPS KAKENHI 16KK0011 and 17H02186. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .