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Anti‐allergic Effect of Dan phenolic acid A from Salvia miltiorrhiza in Ovalbumin‐induced Asthma Model
Author(s) -
Son SoEun,
Heo JaeYeong,
Im DongSoon
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.681.7
Subject(s) - salvia miltiorrhiza , ovalbumin , asthma , degranulation , pharmacology , in vivo , chemistry , medicine , immunology , biochemistry , antigen , biology , traditional chinese medicine , alternative medicine , receptor , microbiology and biotechnology , pathology
Background In Oriental countries, the root of Salvia miltiorrhiza is used to treat cardiovascular diseases, asthma, and other conditions. Dan phenolic acid B from S. miltiorrhiza extracts has been shown to improve airway hyperresponsiveness. We aimed to investigate the effects of Dan phenolic acid A and Dan Shen ketone from S. miltiorrhiza in allergic asthma using female Balb/c mice and rat RBL‐2H3 mast cells. METHODS To elucidate whether Dan phenolic acid A, a constuent of Salvia miltiorrhiza extract has beneficial effects on allergic asthma, anti‐asthma effects were studied using female Balb/c mice and rat RBL‐2H3 mast cells. Antigen‐induced degranulation was assessed by measuring b‐hexosaminidase activity in vitro . In addition, a murine ovalbumin‐induced allergic asthma model was used to test the in vivo efficacy of Dan phenolic acid A and Dan Shen ketone. RESULTS Antigen‐induced degranulation was inhibited by Dan phenolic acid A and Dan Shen ketone. Sensitization and challenge of ovalbumin induced allergic asthma responses. Administration of Dan phenolic acid A and Dan Shen ketone decreased numbers of inflammatory cells, especially eosinophils, and reduced the expression and secretion of Th2 cytokines, including IL‐4 and IL‐13, in lung tissues and bronchoalveolar lavage fluid. Histologic studies showed administration of Dan phenolic acid A and Dan Shen ketone reduced inflammatory signs and mucin production in lungs. CONCLUSION These findings provide evidence that Dan phenolic acid A and Dan Shen ketone have a potential use as anti‐allergic therapeutics. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .