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Mean Platelet Volume in Patients with Regulated and Unregulated Type 2 Diabetes Mellitus According to Sex
Author(s) -
Kama Tabitha Supriya,
Nayakanti Abraham Ratna J,
CS Jaya Prakash,
Srinivasan KR,
Koteswary R
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.662.23
Subject(s) - mean platelet volume , medicine , platelet , diabetes mellitus , dyslipidemia , type 2 diabetes mellitus , glycated hemoglobin , fibrinolysis , platelet activation , thrombosis , gastroenterology , endocrinology , type 2 diabetes
Type 2 diabetes mellitus(DM) is a metabolic disorder with a prevalence of 8.8% in adults in India and 425 million cases worldwide. The high prevalence and morbidity make it a worldwide health problem. Type 2 DM is a part of metabolic syndrome which comprises of hypertension, dyslipidemia, increased procoagulation factors and impaired fibrinolysis. HbA1c is a Glycated hemoglobin is a form of hemoglobin that is measured primarily to identify the three‐month average plasma glucose concentration in diabetics and is measured by automated ion‐exchange high performance liquid chromatography (Bio‐Rad Variant II, Hercules, CA). Hyperglycemia in diabetic patients is thought to have a harmful effect on the blood vessels. Platelet volume is a marker of platelet function and activation. It can be quantified as mean platelet volume (MPV) by clinical hematology analyzers. Platelets are involved in homeostatic process and have an important role in atherosclerosis and arterial thrombosis. When vascu‐lar injury occurs, platelets adhere to dam‐aged endothelium to form platelet plug. It has been reported that plate‐lets from diabetic patients synthesize more thromboxane than normal platelets. To compare the MPV between regulated (HbA1c<6.5%) and nonregulated (HbA1c > 6.5%) diabetics. MATERIALS AND METHODS Study design‐ Cross sectional study, Study duration‐ 06 months; February 2018–July 2018. Sample size‐ Based on the article the proportion used to measure the parameter MPV is 8.8% with an alpha of 5 % the corresponding z value is ‐1.95996398454005. Using the below formula with the minimum percentage difference to be deemed clinically significant as 4.7%. The study outlines the importance of MPV in regulated and non regulated type 2 DM. Support or Funding Information ASIP This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .