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Amygdalin improves burn wound healing in diabetic rats
Author(s) -
Haidar Hanine,
Lauricella Marianna,
Jurjus Rosalyn,
Daouk Hisham,
Leone Angelo,
Capello Francesco,
Eid Assaad,
Jurjus Abdo
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.662.17
Subject(s) - amygdalin , medicine , wound healing , inflammation , diabetes mellitus , regeneration (biology) , burn wound , surgery , endocrinology , pathology , biology , microbiology and biotechnology , alternative medicine
The skin has a unique plasticity and regenerative abilities which are partly impaired in diabetics. On the other hand, amygdalin or vitamin B17 has an array of functions affecting inflammation and cell regeneration. Aim This study aimed to assess the effect of amygdalin on burn wound healing in diabetic rats Materials and methods Sixty‐four male Sprague‐Dawley rats were subjected to burn according to standard published models. Diabetes was induced by sterptozocin and treatment by vitamin B17 followed every other day for 28 days, the duration of the experiment. Biopsies were taken on days 1, 3, 7, 14, and 28 for light microscopy evaluation and cytokines modulation. Results Histological assessment of the burn wounds showed a remarkable improvement in earlier healing, smaller wound area and a better scar in the amygdalin treated group. In addition, a significant decrease in the inflammatory cytokines (IL‐1α, Il‐6 and IL‐12) was noted. Conclusion Amygdalin improved burn wound healing in diabetic rats, in quality and time. Support or Funding Information Ph D Program (University of Palermo and American University of Beirut) This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .