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Aqueous Gladiolus psittacinus Bulb Extract Influences Antioxidant Enzymes Activities in Diabetic Rats
Author(s) -
Oyetayo Folake Lucy,
Oseni Olatunde Abass
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.652.16
Subject(s) - alloxan , antioxidant , superoxide dismutase , chemistry , lipid peroxidation , bulb , catalase , diabetes mellitus , biochemistry , endocrinology , medicine , pharmacology , biology , botany
Aqueous extract of the bulb of Gladiolus psittascinus a tropical plant used as adjunct in the preparation of a non‐alcoholic drink was evaluated for its antioxidant activities in diabetic albino rats. After a 14‐day acclimatization period, rats were divided into five treatment groups of four animals per group as follows: Group 1: Control (Uninduced), Group 2: Alloxan induced diabetic rats, Group 3: Alloxan induced rats treated with standard drug, Group 4: Un‐induced rats treated 100mg/kg body weight aqueous Gladilous psittascinus bulb extract, Group 5: Alloxan induced diabetic rats treated 100mg/kg body weight aqueous Gladilous psittascinus bulb extract. On the establishment of hyperglycemia, animals were sacrificed; plasma antioxidant enzyme activities and lipid peroxidation levels were estimated. Activities of all antioxidant enzymes evaluated increased significantly. Plasma superoxide dismutase activity significantly increased (p<0.05) in the diabetic untreated rats from13.76±2.50U/L (Group 2) to 45.76±5.40U/L in the diabetic aqueous Gladilous psittascinus bulb extract treated rats (Group 5). Furthermore, Catalase activity in the diabetic group (2.48±0.43U/L) significantly increased (p<0.05) to 10.49±1.98U/L in the diabetic aqueous Gladiolus psittascinus bulb extract treated rats (Group 5) and there was a significant decrease in lipid peroxidation levels in plasma from 13.23±3.14 μmolMDA/L (Group 2) to 6.28±1.05 μmolMDA/L (Group 5). The foregoing shows the potentials of aqueous Gladilous psittascinus bulb extract in enhancing the production of antioxidant enzymes required to scavenge reactive oxygen species produced in the diabetic state. Hence, the Gladilous psittascinus bulb holds promise for the food industry in the control of oxidative changes that may occur during food processing and diet therapy in the management of oxidative stress related disorders such as Diabetes mellitus. Support or Funding Information Tertiary Education Trust Fund (TETFUND) through Ekiti State University Ado‐Ekiti, Nigeria This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .