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Selenium Reduces Lectin‐Like Oxidized LDL Receptor‐1 (LOX‐1)‐ Mediated Vascular Oxidative Stress Induced by Inhalation of Pyrolysis Oil Vapors
Author(s) -
Moustafa Mohamed ElSayed,
Fawaz Youssef B.
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.651.17
Subject(s) - oxidative stress , chemistry , malondialdehyde , nadph oxidase , selenium , enos , pharmacology , inhalation , nox , biochemistry , nitric oxide , medicine , anesthesia , organic chemistry , nitric oxide synthase , combustion
Pyrolysis oil (PO) is a renewable fuel produced from municipal solid waste and there is a concern about the adverse effects of its vapors on vascular oxidative stress. In this study, we investigated the effects of exposing mice to PO vapors on lectin‐like oxidized LDL receptor‐1 (LOX‐1)‐mediated vascular oxidative stress. We also examined the effects of selenium supplementation in these mice. Our results showed that the exposure of mice to PO vapors increased aortic levels of malondialdehyde, LOX‐1 and its soluble form sLOX‐1, NADPH oxidase 4 (NOX‐4), NF‐kB (p65) and endothelial NOS (eNOS). The administration of 1.78 μg selenium/kg body weight into these mice 15 minutes before the exposure to PO vapors reduced the increased levels of the above parameters. In conclusion, the exposure to pyrolysis oil vapors contributes to the increased LOX‐1–mediated vascular oxidative stress which can be reduced with selenium supplementation. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .