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Hypoglycemia effect of drink containing Guava Leaf Extract in Rats with type 2 diabetic rats
Author(s) -
Huang HuiYu,
Chen LiHan,
Chan ChingHung
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2019.33.1_supplement.651.10
Subject(s) - psidium , streptozotocin , hypoglycemia , endocrinology , medicine , diabetes mellitus , antioxidant , fructose , interleukin 6 , tumor necrosis factor alpha , interleukin , chemistry , biology , cytokine , biochemistry , botany
This study investigated the effect of drink containing Guava Leaf Extract (GLE) (Psidium guajava Linn.) on hypoglycemia and glucose metabolism in type 2 diabetic rats. High fat‐fructose Diet and Low‐dose streptozotocin (STZ) and nicotinamide were given and injected into Sprague‐Dawley (SD) rats to induce type 2 diabetes. Fifty rats were equally assigned into diabetes mellitus group (DM), positive control group (PC), low‐dose GLE group (L), medium‐dose GLE group (M), and high‐dose GLE group (H) respectively. We found that GLE progressively decreased fasting blood glucose and OGTT (□ < 0.01). Elevated pro‐inflammatory cytokines, interleukin‐1β (IL‐1β), IL‐6, and tumor necrosis factor‐α (TNF‐α), were controlled by L, M and H group. Antioxidant activity was increased in L, M and H group. Experimental evidences demonstrate that GLE may be effective alternative medicine to prevent HFFD‐induced hyperglycemia and hyperlipidemia, possibly associated with anti‐inflammatory and antioxidant efficacies. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .